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Chronic infection

MedGen UID:
508751
•Concept ID:
C0151317
•
Disease or Syndrome
Synonyms: Chronic Infection; Chronic Infections; Infection, Chronic
SNOMED CT: Chronic infectious disease (177010002)
 
HPO: HP:0031035

Definition

Presence of a protracted or persistent infection by a pathogen potentially related to an underlying abnormality of the immune system that is not able to clear the infection. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChronic infection

Professional guidelines

PubMed

Hepatitis E virus: Epidemiology, diagnosis, clinical manifestations, and treatment.
Aslan AT, Balaban HY
World J Gastroenterol 2020 Oct 7;26(37):5543-5560. doi: 10.3748/wjg.v26.i37.5543. PMID: 33071523Free PMC Article
Hepatitis B: Screening, Prevention, Diagnosis, and Treatment.
Wilkins T, Sams R, Carpenter M
Am Fam Physician 2019 Mar 1;99(5):314-323. PMID: 30811163
EASL 2017 Clinical Practice Guidelines on the management of hepatitis B virus infection.
European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu; European Association for the Study of the Liver
J Hepatol 2017 Aug;67(2):370-398. Epub 2017 Apr 18 doi: 10.1016/j.jhep.2017.03.021. PMID: 28427875

Recent clinical studies

Etiology

Molecular mechanisms of viral hepatitis induced hepatocellular carcinoma.
D'souza S, Lau KC, Coffin CS, Patel TR
World J Gastroenterol 2020 Oct 14;26(38):5759-5783. doi: 10.3748/wjg.v26.i38.5759. PMID: 33132633Free PMC Article
Current cancer situation in China: good or bad news from the 2018 Global Cancer Statistics?
Feng RM, Zong YN, Cao SM, Xu RH
Cancer Commun (Lond) 2019 Apr 29;39(1):22. doi: 10.1186/s40880-019-0368-6. PMID: 31030667Free PMC Article
Chronic Infection and Severe Asthma.
Carr TF, Kraft M
Immunol Allergy Clin North Am 2016 Aug;36(3):483-502. Epub 2016 Jun 2 doi: 10.1016/j.iac.2016.03.010. PMID: 27401621
Coccidioidomycosis: Recent Updates.
Twarog M, Thompson GR 3rd
Semin Respir Crit Care Med 2015 Oct;36(5):746-55. Epub 2015 Sep 23 doi: 10.1055/s-0035-1562900. PMID: 26398540
Hepatitis B.
Lin KW, Kirchner JT
Am Fam Physician 2004 Jan 1;69(1):75-82. PMID: 14727820

Diagnosis

Exosomes in HBV infection.
Liu Z, Li Y, Wang Y, Bai X, Zhang Y
Clin Chim Acta 2023 Jan 1;538:65-69. Epub 2022 Nov 12 doi: 10.1016/j.cca.2022.11.012. PMID: 36375524
Molecular mechanisms of viral hepatitis induced hepatocellular carcinoma.
D'souza S, Lau KC, Coffin CS, Patel TR
World J Gastroenterol 2020 Oct 14;26(38):5759-5783. doi: 10.3748/wjg.v26.i38.5759. PMID: 33132633Free PMC Article
Current cancer situation in China: good or bad news from the 2018 Global Cancer Statistics?
Feng RM, Zong YN, Cao SM, Xu RH
Cancer Commun (Lond) 2019 Apr 29;39(1):22. doi: 10.1186/s40880-019-0368-6. PMID: 31030667Free PMC Article
Position statement: LEPROSY: Diagnosis, treatment and follow-up.
Alemu Belachew W, Naafs B
J Eur Acad Dermatol Venereol 2019 Jul;33(7):1205-1213. Epub 2019 Apr 3 doi: 10.1111/jdv.15569. PMID: 30945360
Pseudomonas aeruginosa infection in cystic fibrosis: pathophysiological mechanisms and therapeutic approaches.
Lund-Palau H, Turnbull AR, Bush A, Bardin E, Cameron L, Soren O, Wierre-Gore N, Alton EW, Bundy JG, Connett G, Faust SN, Filloux A, Freemont P, Jones A, Khoo V, Morales S, Murphy R, Pabary R, Simbo A, Schelenz S, Takats Z, Webb J, Williams HD, Davies JC
Expert Rev Respir Med 2016 Jun;10(6):685-97. Epub 2016 May 13 doi: 10.1080/17476348.2016.1177460. PMID: 27175979

Therapy

The path to eradication of rubella.
Reef SE, Icenogle JP, Plotkin SA
Vaccine 2023 Dec 7;41(50):7525-7531. Epub 2023 Nov 14 doi: 10.1016/j.vaccine.2023.11.014. PMID: 37973510
Precision Medicine Approach to Alzheimer's Disease: Successful Pilot Project.
Toups K, Hathaway A, Gordon D, Chung H, Raji C, Boyd A, Hill BD, Hausman-Cohen S, Attarha M, Chwa WJ, Jarrett M, Bredesen DE
J Alzheimers Dis 2022;88(4):1411-1421. doi: 10.3233/JAD-215707. PMID: 35811518Free PMC Article
Hepatitis B virus-specific CD4 T cell responses differentiate functional cure from chronic surface antigen(+) infection.
Hoogeveen RC, Dijkstra S, Bartsch LM, Drescher HK, Aneja J, Robidoux MP, Cheney JA, Timm J, Gehring A, de Sousa PSF, Ximenez L, Peliganga LB, Pitts A, Evans FB, Boonstra A, Kim AY, Lewis-Ximenez LL, Lauer GM
J Hepatol 2022 Nov;77(5):1276-1286. Epub 2022 Jun 15 doi: 10.1016/j.jhep.2022.05.041. PMID: 35716846
Pseudomonas aeruginosa infection in cystic fibrosis: pathophysiological mechanisms and therapeutic approaches.
Lund-Palau H, Turnbull AR, Bush A, Bardin E, Cameron L, Soren O, Wierre-Gore N, Alton EW, Bundy JG, Connett G, Faust SN, Filloux A, Freemont P, Jones A, Khoo V, Morales S, Murphy R, Pabary R, Simbo A, Schelenz S, Takats Z, Webb J, Williams HD, Davies JC
Expert Rev Respir Med 2016 Jun;10(6):685-97. Epub 2016 May 13 doi: 10.1080/17476348.2016.1177460. PMID: 27175979
Sporotrichosis.
Davis BA
Dermatol Clin 1996 Jan;14(1):69-76. doi: 10.1016/s0733-8635(05)70326-0. PMID: 8821159

Prognosis

Is it possible to halve the incidence of liver cancer in China by 2050?
Shi JF, Cao M, Wang Y, Bai FZ, Lei L, Peng J, Feletto E, Canfell K, Qu C, Chen W
Int J Cancer 2021 Mar 1;148(5):1051-1065. Epub 2020 Oct 16 doi: 10.1002/ijc.33313. PMID: 32997794
Liver diseases in the Asia-Pacific region: a Lancet Gastroenterology & Hepatology Commission.
Sarin SK, Kumar M, Eslam M, George J, Al Mahtab M, Akbar SMF, Jia J, Tian Q, Aggarwal R, Muljono DH, Omata M, Ooka Y, Han KH, Lee HW, Jafri W, Butt AS, Chong CH, Lim SG, Pwu RF, Chen DS
Lancet Gastroenterol Hepatol 2020 Feb;5(2):167-228. Epub 2019 Dec 15 doi: 10.1016/S2468-1253(19)30342-5. PMID: 31852635Free PMC Article
Current cancer situation in China: good or bad news from the 2018 Global Cancer Statistics?
Feng RM, Zong YN, Cao SM, Xu RH
Cancer Commun (Lond) 2019 Apr 29;39(1):22. doi: 10.1186/s40880-019-0368-6. PMID: 31030667Free PMC Article
The eradication of HCV.
De Nicola S, Colombo M
Minerva Gastroenterol Dietol 2016 Mar;62(1):63-75. Epub 2015 Oct 7 PMID: 26446686
Hepatitis A.
Matheny SC, Kingery JE
Am Fam Physician 2012 Dec 1;86(11):1027-34; quiz 1010-2. PMID: 23198670

Clinical prediction guides

Alternative B Cell Differentiation During Infection and Inflammation.
Courey-Ghaouzi AD, Kleberg L, Sundling C
Front Immunol 2022;13:908034. Epub 2022 Jun 24 doi: 10.3389/fimmu.2022.908034. PMID: 35812395Free PMC Article
Precision Medicine Approach to Alzheimer's Disease: Successful Pilot Project.
Toups K, Hathaway A, Gordon D, Chung H, Raji C, Boyd A, Hill BD, Hausman-Cohen S, Attarha M, Chwa WJ, Jarrett M, Bredesen DE
J Alzheimers Dis 2022;88(4):1411-1421. doi: 10.3233/JAD-215707. PMID: 35811518Free PMC Article
Comparing encounter-based and annualized chronic pseudomonas infection definitions in cystic fibrosis.
Rosenfeld M, Faino AV, Onchiri F, Aksit MA, Blackman SM, Blue EE, Collaco JM, Gordon WW, Pace RG, Raraigh KS, Zhou YH, Cutting GR, Knowles MR, Bamshad MJ, Gibson RL
J Cyst Fibros 2022 Jan;21(1):40-44. Epub 2021 Aug 13 doi: 10.1016/j.jcf.2021.07.020. PMID: 34393091
Coccidioidomycosis: Recent Updates.
Twarog M, Thompson GR 3rd
Semin Respir Crit Care Med 2015 Oct;36(5):746-55. Epub 2015 Sep 23 doi: 10.1055/s-0035-1562900. PMID: 26398540
HIV and the spectrum of human disease.
Lucas S, Nelson AM
J Pathol 2015 Jan;235(2):229-41. doi: 10.1002/path.4449. PMID: 25251832

Recent systematic reviews

The present roles and future perspectives of Interleukin-6 in biliary tract cancer.
Zhou M, Na R, Lai S, Guo Y, Shi J, Nie J, Zhang S, Wang Y, Zheng T
Cytokine 2023 Sep;169:156271. Epub 2023 Jun 16 doi: 10.1016/j.cyto.2023.156271. PMID: 37331095
Efficacy and safety of antiviral prophylaxis during pregnancy to prevent mother-to-child transmission of hepatitis B virus: a systematic review and meta-analysis.
Funk AL, Lu Y, Yoshida K, Zhao T, Boucheron P, van Holten J, Chou R, Bulterys M, Shimakawa Y
Lancet Infect Dis 2021 Jan;21(1):70-84. Epub 2020 Aug 14 doi: 10.1016/S1473-3099(20)30586-7. PMID: 32805200
Trachoma.
Lansingh VC
BMJ Clin Evid 2016 Feb 9;2016 PMID: 26860629Free PMC Article
Toxoplasmosis and epilepsy--systematic review and meta analysis.
Ngoungou EB, Bhalla D, Nzoghe A, Dardé ML, Preux PM
PLoS Negl Trop Dis 2015 Feb;9(2):e0003525. Epub 2015 Feb 19 doi: 10.1371/journal.pntd.0003525. PMID: 25695802Free PMC Article
Trachoma.
Solomon A, Mabey D
BMJ Clin Evid 2007 Nov 7;2007 PMID: 19450349Free PMC Article

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